Childhood cancers like Rhabdomyosarcoma, Wilms' tumor, and Neuroblastoma are rare but impactful. Rhabdomyosarcoma affects soft tissues, Wilms' tumor targets the kidneys, and Neuroblastoma develops in nerve tissue. Diagnosis involves imaging and biopsy, with treatment often including surgery, chemotherapy, and radiation to manage and prevent recurrence. Early detection and a multidisciplinary approach are key to improving outcomes.